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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DNASE1L1
All Species:
7.88
Human Site:
T222
Identified Species:
19.26
UniProt:
P49184
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49184
NP_001009932.1
302
33893
T222
D
T
T
V
R
A
S
T
H
C
T
Y
D
R
V
Chimpanzee
Pan troglodytes
XP_001174037
305
35527
T223
L
I
G
D
Q
E
D
T
T
V
K
K
S
T
N
Rhesus Macaque
Macaca mulatta
XP_001097104
305
35444
T223
L
I
G
D
Q
E
D
T
T
V
K
R
S
T
K
Dog
Lupus familis
XP_549370
295
33342
T215
V
I
A
D
G
E
D
T
T
V
R
A
S
T
H
Cat
Felis silvestris
Mouse
Mus musculus
Q9D7J6
314
35586
R235
D
G
E
D
T
T
V
R
A
S
T
N
C
T
Y
Rat
Rattus norvegicus
Q2QDE7
312
35163
T218
L
N
S
L
L
L
R
T
K
A
G
F
H
W
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506333
315
35674
V231
F
N
A
G
C
S
Y
V
S
A
S
S
W
S
A
Chicken
Gallus gallus
Q9YGI5
282
31382
S203
V
T
A
E
Q
W
P
S
I
R
L
R
S
L
S
Frog
Xenopus laevis
NP_001090620
297
33927
T215
D
T
T
V
R
G
S
T
N
C
A
Y
D
R
I
Zebra Danio
Brachydanio rerio
NP_001002403
292
34004
P210
N
V
R
L
R
S
D
P
K
F
H
W
L
I
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
40
40.3
80.1
N.A.
66.5
66.9
N.A.
35.8
36
42.7
43
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
61.6
61.3
85
N.A.
75.4
75.9
N.A.
53.9
54.9
61.9
61.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
6.6
6.6
N.A.
13.3
13.3
N.A.
0
6.6
73.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
13.3
6.6
N.A.
13.3
33.3
N.A.
13.3
20
86.6
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
30
0
0
10
0
0
10
20
10
10
0
0
10
% A
% Cys:
0
0
0
0
10
0
0
0
0
20
0
0
10
0
0
% C
% Asp:
30
0
0
40
0
0
40
0
0
0
0
0
20
0
0
% D
% Glu:
0
0
10
10
0
30
0
0
0
0
0
0
0
0
0
% E
% Phe:
10
0
0
0
0
0
0
0
0
10
0
10
0
0
0
% F
% Gly:
0
10
20
10
10
10
0
0
0
0
10
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
10
0
10
0
10
0
10
% H
% Ile:
0
30
0
0
0
0
0
0
10
0
0
0
0
10
10
% I
% Lys:
0
0
0
0
0
0
0
0
20
0
20
10
0
0
10
% K
% Leu:
30
0
0
20
10
10
0
0
0
0
10
0
10
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
20
0
0
0
0
0
0
10
0
0
10
0
0
10
% N
% Pro:
0
0
0
0
0
0
10
10
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
30
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
10
0
30
0
10
10
0
10
10
20
0
20
10
% R
% Ser:
0
0
10
0
0
20
20
10
10
10
10
10
40
10
10
% S
% Thr:
0
30
20
0
10
10
0
60
30
0
20
0
0
40
0
% T
% Val:
20
10
0
20
0
0
10
10
0
30
0
0
0
0
20
% V
% Trp:
0
0
0
0
0
10
0
0
0
0
0
10
10
10
0
% W
% Tyr:
0
0
0
0
0
0
10
0
0
0
0
20
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _